RAB6A抗体

Rab6A antibody is a tool used to detect Rab6A, a member of the Rab GTPase family involved in regulating intracellular vesicle trafficking. Rab6A localizes primarily to the Golgi apparatus and associated vesicles, where it plays a key role in retrograde transport (Golgi-to-endoplasmic reticulum) and secretory pathways. It also participates in mitosis by mediating membrane trafficking during cell division. The antibody targets specific epitopes of Rab6A, enabling its visualization and quantification in techniques like Western blotting, immunofluorescence, and immunoprecipitation. Researchers utilize Rab6A antibodies to study its role in cellular processes such as secretion, autophagy, and signaling, as well as its dysregulation in diseases like cancer, neurodegenerative disorders, and viral infections. Rab6A isoforms (Rab6A and Rab6A') may exhibit functional differences, requiring antibody specificity validation. Commercial Rab6A antibodies are typically raised in rabbits or mice, with validation through knockout cell lines or siRNA knockdown to confirm target specificity. Understanding Rab6A dynamics through these antibodies contributes to insights into intracellular logistics and disease mechanisms.