UBXN2A抗体

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     Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane: Mouse liver tissue, Primary antibody: P03747(UBXN2A Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 seconds    

  
  

The UBXN2A antibody is a valuable tool for studying the ubiquitin regulatory system, specifically targeting the UBXN2A protein (Ubiquitin-like Domain-Containing Protein 2A). UBXN2A, also known as UBX domain protein 2A, is a member of the UBX domain-containing protein family, characterized by a conserved UBX domain that facilitates interactions with ubiquitin-related machinery. This protein plays roles in modulating ubiquitin-dependent processes, including protein degradation via the ubiquitin-proteasome system (UPS) and regulation of endoplasmic reticulum-associated degradation (ERAD). It has been implicated in cellular stress responses, apoptosis, and maintaining protein homeostasis.

UBXN2A antibodies are widely used in research to investigate its expression levels, subcellular localization, and interactions with partners like valosin-containing protein (VCP/p97), a key ATPase in ERAD. Studies suggest UBXN2A may act as a cofactor or regulator of p97. influencing pathways linked to cancer, neurodegenerative diseases (e.g., ALS), and viral infection responses. Researchers employ these antibodies in techniques such as Western blotting, immunofluorescence, immunoprecipitation, and immunohistochemistry to explore UBXN2A's functional mechanisms. Commercial antibodies are typically validated for specificity, often through knockdown/knockout controls, to ensure reliable detection of the ~45 kDa protein. Ongoing research aims to clarify its dual roles in promoting or inhibiting disease pathways, depending on cellular context.