RAB17抗体

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     The image is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using P03722(RAB17 Antibody) at dilution 1/30. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P03722(RAB17 Antibody) at dilution 1/30. (Original magnification: ×200)    

  
  

The RAB17 antibody is a crucial tool for studying the RAB17 protein, a member of the RAB GTPase family involved in intracellular vesicular trafficking and membrane dynamics. RAB17. primarily expressed in polarized cells like epithelial and neuronal cells, regulates endocytic recycling, receptor transport, and cell signaling. It plays roles in processes such as autophagy, cell migration, and maintaining epithelial polarity, with dysregulation linked to cancers, neurodegenerative disorders, and developmental defects.

RAB17 antibodies enable researchers to detect, localize, and quantify RAB17 expression in cells or tissues using techniques like Western blotting, immunofluorescence, and immunohistochemistry. These antibodies are essential for investigating RAB17's functional mechanisms, interactions with effector proteins (e.g., RAB-interacting lysosomal protein/RILP), and its involvement in disease pathways. Monoclonal antibodies offer high specificity, while polyclonal versions may detect multiple epitopes. Validated antibodies often include knockout (KO) controls or siRNA knockdown data to confirm target specificity.

Commercial RAB17 antibodies are widely used in cancer research (e.g., studying metastasis) and neurobiology (e.g., synaptic vesicle trafficking). Their development and optimization continue to advance understanding of RAB17's role in cellular homeostasis and pathology.