ZFYVE19 抗体

+ +

•  

   

     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Hela cells, A431 cells, Primary antibody: P03693(ZFYVE19   Antibody) at dilution 1/500, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 20 seconds    

  
  

•  

   

     The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P03693(ZFYVE19 ? Antibody) at dilution 1/61. (Original magnification: ×200)    

  
  

•  

   

     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P03693(ZFYVE19   Antibody) at dilution 1/61. (Original magnification: ×200)    

  
  

The ZFYVE19 antibody is a research tool designed to target the ZFYVE19 protein, encoded by the ZFYVE19 gene (zinc finger FYVE-type containing 19), also known as MITOLIN. This protein localizes to mitochondria and plays a role in mitochondrial dynamics, membrane trafficking, and autophagy. It contains a FYVE domain, which binds phosphatidylinositol 3-phosphate (PI3P), facilitating its interaction with lipid membranes. ZFYVE19 has been implicated in regulating mitochondrial morphology and quality control, particularly through mitophagy, a selective autophagy process that removes damaged mitochondria.

Interest in ZFYVE19 antibodies arose from studies linking ZFYVE19 mutations to human diseases. Biallelic pathogenic variants in ZFYVE19 were identified in patients with a rare congenital disorder characterized by neonatal cholestasis, progressive liver fibrosis, and mitochondrial abnormalities. Research using ZFYVE19 antibodies has helped elucidate the protein's role in maintaining mitochondrial integrity and its dysfunction in disease pathogenesis. These antibodies are commonly used in techniques like Western blotting, immunofluorescence, and immunohistochemistry to study ZFYVE19 expression, subcellular localization, and interactions in cellular and disease models. Recent studies also explore its potential crosstalk with other mitochondrial proteins, such as those involved in membrane fusion/fission. Commercial ZFYVE19 antibodies are typically validated in human or murine samples, aiding mechanistic research into mitochondrial disorders and liver diseases.