ZBTB6 抗体

+ +

•  

   

     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P03683(ZBTB6 ? Antibody) at dilution 1/50. (Original magnification: ×200)    

  
  

The ZBTB6 antibody is a research tool designed to detect and study the ZBTB6 protein, a member of the zinc finger and BTB domain-containing (ZBTB) protein family. ZBTB6. also known as ZID or ZNF503. functions as a transcriptional regulator, influencing gene expression by binding to DNA through its C2H2-type zinc finger motifs. It contains a BTB/POZ domain, which mediates protein-protein interactions, and is implicated in diverse cellular processes, including cell differentiation, proliferation, and apoptosis.

ZBTB6 antibodies are widely used in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to analyze protein expression, localization, and regulatory roles in various tissues and disease models. Studies suggest ZBTB6 participates in developmental pathways and cancer progression, with altered expression observed in malignancies like gliomas and colorectal cancer. Its role in modulating signaling pathways, such as Wnt/β-catenin or Notch, highlights its potential as a therapeutic target or biomarker.

Research utilizing ZBTB6 antibodies has advanced understanding of its dual transcriptional repressor/activator functions and its interplay with chromatin-modifying complexes. However, variability in antibody specificity and validation across experimental models requires careful optimization. Ongoing studies aim to clarify ZBTB6's context-dependent mechanisms in health and disease.