ZBTB1 抗体

The ZBTB1 antibody is a tool used to detect the ZBTB1 protein, a member of the zinc finger and BTB domain-containing (ZBTB) family. ZBTB1. also known as ZNF909. functions as a transcriptional regulator involved in immune system modulation, particularly in T-cell development and differentiation. Structurally, it contains a BTB (Broad-Complex, Tramtrack, and Bric-à-brac) domain at the N-terminus, which mediates protein-protein interactions, and multiple C2H2 zinc finger motifs at the C-terminus for DNA binding. This protein plays roles in chromatin remodeling, gene silencing, and maintaining immune homeostasis. Antibodies targeting ZBTB1 are widely employed in research to study its expression patterns, subcellular localization, and molecular interactions. They are utilized in techniques such as Western blotting, immunohistochemistry, and immunoprecipitation. Studies have linked ZBTB1 to immune-related pathways, including NF-κB signaling, and its dysregulation has been implicated in autoimmune disorders and hematological malignancies. The development of specific ZBTB1 antibodies has advanced understanding of its dual roles as both a transcriptional repressor and an immune checkpoint modulator, highlighting its potential as a therapeutic target. Commercial antibodies are typically validated for specificity using knockout cell lines or siRNA-based knockdown approaches.