STUB1抗体

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     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: 293T cell lysate, Primary antibody: P03662(STUB1 Antibody) at dilution 1/1000, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 10 seconds    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P03662(STUB1 Antibody) at dilution 1/75. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using P03662(STUB1 Antibody) at dilution 1/75. (Original magnification: ×200)    

  
  

The STUB1 antibody targets the STUB1 protein, also known as CHIP (C-terminus of HSC70-interacting protein), an E3 ubiquitin ligase critical for cellular protein quality control. STUB1 facilitates ubiquitination of misfolded or damaged proteins, marking them for degradation via the ubiquitin-proteasome system. It interacts with molecular chaperones like Hsp70/Hsc70 and Hsp90. linking protein folding to degradation pathways. STUB1 is implicated in diverse physiological processes, including stress response, apoptosis, and neurodegeneration. Dysregulation of STUB1 is associated with neurological disorders (e.g., spinocerebellar ataxia, Alzheimer’s disease) and cancers, where it may act as a tumor suppressor or promoter depending on context.

Antibodies against STUB1 are widely used in research to detect its expression, localization, and interaction partners through techniques like Western blotting, immunohistochemistry, and immunoprecipitation. They help elucidate STUB1’s role in proteostasis, disease mechanisms, and therapeutic targeting. Commercial STUB1 antibodies vary in clonality (monoclonal/polyclonal), species reactivity, and epitope specificity, requiring validation for experimental conditions. Researchers often utilize these antibodies to study STUB1’s dual roles in protein degradation and cellular stress adaptation, offering insights into diseases linked to proteotoxic stress.