WDR74 抗体

The WDR74 antibody is a research tool designed to detect and study the WDR74 protein, a member of the WD-repeat protein family characterized by conserved WD40 domains that facilitate protein-protein interactions. WDR74 is implicated in ribosome biogenesis, particularly in rRNA processing and nucleolar functions, playing a role in cellular proliferation and differentiation. Studies suggest its involvement in coordinating ribosomal subunit assembly, potentially linking it to cell cycle regulation and stress responses. Dysregulation of WDR74 has been associated with cancers, including hepatocellular carcinoma and gastric cancer, where overexpression may drive tumor progression. The antibody, typically developed in rabbit or mouse hosts, enables applications like Western blotting, immunohistochemistry, and immunofluorescence to localize WDR74 in tissues or cultured cells. Its use aids in exploring WDR74’s molecular interactions, expression patterns under physiological or pathological conditions, and validation in gene-editing models. Recent research highlights its interaction with components of the RNA polymerase I machinery and nucleolar stress pathways, underscoring its importance in ribosomopathies and oncogenesis. However, functional insights remain emerging, necessitating further studies to define its precise mechanisms. The WDR74 antibody thus serves as a critical reagent for dissecting its biological roles and potential as a therapeutic target.