WDR6 抗体

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     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Hela cells, NIH/3T3 cells, Primary antibody: P03657(WDR6   Antibody) at dilution 1/1000, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 2 minutes    

  
  

The WDR6 (WD repeat domain 6) protein is a member of the WD-repeat protein family, characterized by conserved repeats of ~40 amino acids typically forming β-propeller structures that mediate protein-protein interactions. WDR6 is implicated in diverse cellular processes, including transcriptional regulation, ribosome biogenesis, and epigenetic modifications. It interacts with multiple molecular partners, such as histone methyltransferases and chromatin remodelers, suggesting roles in chromatin organization and gene expression control. Research links WDR6 to developmental pathways and cellular differentiation, with potential involvement in cell cycle progression and apoptosis.

Antibodies targeting WDR6 are essential tools for studying its expression, localization, and function. They enable detection via techniques like Western blotting, immunofluorescence, and immunohistochemistry. Such antibodies have been used to explore WDR6's association with diseases, including cancer (e.g., glioblastoma, hepatocellular carcinoma) and neurological disorders, where dysregulation of WDR6-related pathways may contribute to pathogenesis. Validation of WDR6 antibodies often includes knockout cell line controls to confirm specificity. Ongoing research aims to clarify WDR6's mechanistic roles and its potential as a therapeutic target, driving demand for reliable antibodies in both basic and translational studies.