VMA21抗体

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     The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P03636(VMA21 Antibody) at dilution 1/150. (Original magnification: ×200)    

  
  

**Background of VMA21 Antibody**

The VMA21 antibody is a tool used to study VMA21. a critical chaperone protein involved in the assembly of vacuolar ATPases (V-ATPases). V-ATPases are multi-subunit proton pumps responsible for acidifying intracellular compartments, such as lysosomes and endosomes, which is essential for processes like protein degradation, autophagy, and cellular signaling. VMA21 specifically facilitates the maturation of the V-ATPase V0 domain by aiding the glycosylation and stabilization of its subunit *a* isoforms during endoplasmic reticulum (ER)-associated processing.

Mutations in the *VMA21* gene are linked to X-linked myopathy with excessive autophagy (XMEA), a rare genetic disorder characterized by muscle weakness, autophagic vacuolation, and lysosomal dysfunction. Research using VMA21 antibodies has been pivotal in elucidating the molecular mechanisms underlying XMEA, including impaired lysosomal acidification and disrupted autophagy.

VMA21 antibodies are commonly employed in techniques like Western blotting, immunofluorescence, and immunohistochemistry to detect VMA21 expression, localization, and interaction partners in cellular models or patient tissues. These studies help clarify how VMA21 deficiency disrupts cellular homeostasis and contributes to disease pathology. Additionally, the antibody serves as a diagnostic and research reagent for exploring therapeutic strategies targeting V-ATPase assembly or lysosomal function in neuromuscular and lysosomal storage disorders. Its role in fundamental cell biology continues to expand, bridging gaps between basic science and clinical applications.