SLC17A7抗体 新品

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     The image is immunohistochemistry of paraffin-embedded Human brain tissue using P03631(SLC17A7 Antibody) at dilution 1/200. (Original magnification: ×200)    

  
  

The SLC17A7 antibody targets the solute carrier family 17 member 7 (SLC17A7) protein, also known as vesicular glutamate transporter 1 (VGLUT1). This transporter is critical for packaging the neurotransmitter glutamate into synaptic vesicles, enabling glutamatergic signaling in the central nervous system. VGLUT1 is predominantly expressed in excitatory neurons, particularly in the cerebral cortex, hippocampus, and cerebellum, where it regulates synaptic plasticity, learning, and memory.

SLC17A7 antibodies are widely used in neuroscience research to identify and map glutamatergic neurons, study synaptic connectivity, and investigate disorders linked to glutamate dysregulation, such as Alzheimer's disease, epilepsy, and schizophrenia. These antibodies are validated for techniques like immunohistochemistry (IHC), Western blot (WB), and immunofluorescence (IF). Specificity is crucial, as cross-reactivity with other VGLUT isoforms (e.g., VGLUT2 or VGLUT3) could lead to misinterpretation. High-quality SLC17A7 antibodies typically show distinct labeling patterns in brain regions rich in VGLUT1. such as layered cortical structures, aiding in the functional dissection of glutamatergic pathways. Their application has advanced understanding of excitatory neurotransmission and its role in both normal physiology and disease.