SS18L1抗体

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     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Mouse brain tissue lysate, Primary antibody: P03617(SS18L1 Antibody) at dilution 1/550, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 7 seconds    

  
  

The SS18L1 (SS18 Like 1) antibody is a tool used to detect the SS18L1 protein, a homolog of SS18. a component of the SWI/SNF chromatin remodeling complex. SS18L1 shares structural similarities with SS18. including a conserved SNH domain, but lacks the SYT domain found in its counterpart. This protein is implicated in transcriptional regulation, chromatin organization, and cellular differentiation. Research has shown that SS18L1 interacts with transcription factors and other SWI/SNF subunits, influencing gene expression programs critical for development and tissue homeostasis.

The SS18L1 antibody is particularly valuable in studying its role in cancer and neurological disorders. While SS18 is frequently involved in synovial sarcoma due to SS18-SSX fusion genes, SS18L1 has been linked to neural development and diseases like spinocerebellar ataxia. Antibody applications include Western blotting, immunohistochemistry, and immunofluorescence to assess protein expression, localization, and interactions in experimental models.

Validated antibodies against SS18L1 help distinguish it from SS18. aiding research into functional divergence between these paralogs. Recent studies also explore SS18L1's potential as a biomarker or therapeutic target in conditions marked by chromatin dysregulation. Proper validation ensures specificity, minimizing cross-reactivity with SS18 or other family members, which is crucial for accurate interpretation in both basic and translational contexts.