RHPN2抗体

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     Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane 1-5: HepG2, LOVO, SKOV3, A549, 231 cell lysates, Primary antibody: P03577(RHPN2 Antibody) at dilution 1/600, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 30 seconds    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human colorectal cancer tissue using P03577(RHPN2 Antibody) at dilution 1/85. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human tonsil tissue using P03577(RHPN2 Antibody) at dilution 1/85. (Original magnification: ×200)    

  
  

The RHPN2 (Rhophilin Rho GTPase Binding Protein 2) antibody is a tool used to study the RHPN2 protein, a member of the Rhophilin family that interacts with Rho GTPases to regulate cytoskeletal dynamics, cell adhesion, and signaling pathways. RHPN2 contains a conserved N-terminal RH domain for binding active RhoA/C and a C-terminal PDZ-binding motif, enabling interactions with downstream effectors. Dysregulation of RHPN2 has been linked to cancers, neurological disorders, and developmental defects due to its role in cell motility, proliferation, and polarity.

RHPN2 antibodies, typically produced in rabbits or mice, target specific epitopes (e.g., N-terminal or C-terminal regions) and are validated for applications like Western blotting, immunohistochemistry, and immunofluorescence. These antibodies aid in elucidating RHPN2’s expression patterns, subcellular localization, and molecular mechanisms in disease contexts. Commercial RHPN2 antibodies are often characterized for specificity using knockout controls or siRNA-mediated silencing. Research using these reagents has highlighted RHPN2’s involvement in tumor metastasis, neuronal morphogenesis, and cilia function. Their development supports both basic research and potential clinical applications, such as identifying RHPN2 as a biomarker or therapeutic target.