CBWD1抗体

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     The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P02101(CBWD1 Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

The CBWD1 (COBW Domain Containing 1) antibody is a tool used to study the CBWD1 protein, encoded by the *C21orf80* gene in humans. CBWD1 is a conserved, ubiquitously expressed protein implicated in cellular processes such as transcriptional regulation, epigenetic modulation, and cellular stress responses. It interacts with histone acetyltransferase complexes (e.g., PCAF/CBP), influencing chromatin remodeling and gene expression. CBWD1 also binds to vitamin B12 derivatives, suggesting a role in metabolic regulation, though its precise biological functions remain under investigation.

The antibody is commonly employed in techniques like Western blotting, immunoprecipitation, and immunofluorescence to detect CBWD1 expression and localization in tissues or cultured cells. Validated in multiple species (human, mouse, rat), it aids in exploring CBWD1's involvement in diseases, including cancers (e.g., hepatocellular carcinoma) and neurodevelopmental disorders, where altered CBWD1 levels correlate with pathological progression. Researchers prioritize antibodies with high specificity, often verified via knockout controls or siRNA knockdown. Commercial CBWD1 antibodies are typically raised in rabbits or mice, with reactivity confirmed across diverse sample types. Ongoing studies leverage this reagent to dissect CBWD1's molecular mechanisms, particularly its interplay with epigenetic modifiers and metabolic pathways, highlighting its potential as a therapeutic or diagnostic target.