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MMGT1抗体

Rabbit Polyclonal MMGT1 Antibody
询价 20μl 起订
50μl 起订
100μl 起订
湖北 更新日期：2025-05-11

湖北瑞和宁生物科技有限公司

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产品详情:

中文名称：
MMGT1抗体
英文名称：
Rabbit Polyclonal MMGT1 Antibody
品牌：
艾普蒂
产地：
武汉
保存条件：
Stored at -20°C for 2140 year. Avoid repeated freeze / thaw cycles.
产品类别：
抗体
重组：
否
应用：
WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性：
Human,Mouse,Rat
宿主：
Rabbit
偶联物：
无
靶点：
MMGT1

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/20-1/100 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/5000-1/10000 Human,Mouse,Rat
   

产品详情

AliasesEMC5; TMEM32
WB Predicted band size15 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse, Rat
ImmunogenFull length fusion protein
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 12%SDS-PAGE, Lysate: 40 μg, Lane 1-4: Hela, 293T, 231 and PC-3 cell, Primary antibody: P02094(MMGT1 Antibody) at dilution 1/250, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 5 seconds    


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       The image is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using P02094(MMGT1 Antibody) at dilution 1/20. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human lung cancer tissue using P02094(MMGT1 Antibody) at dilution 1/20. (Original magnification: ×200)    


           

参考文献

以下是模拟生成的关于MMGT1抗体的参考文献示例(仅供学术参考，实际文献需通过数据库查询)：

1. **文献名称**：*MMGT1 regulates cellular magnesium transport via antibody-targeted functional analysis*

**作者**：Smith A, et al.

**摘要**：本研究利用特异性MMGT1抗体，验证了该蛋白在细胞镁离子跨膜转运中的关键作用，并发现其表达水平与细胞内镁稳态直接相关。

2. **文献名称**：*Development of a monoclonal antibody for MMGT1 and its application in cancer cell proliferation studies*

**作者**：Zhang L, et al.

**摘要**：通过制备高亲和力MMGT1单克隆抗体，揭示了MMGT1在肿瘤细胞(如乳腺癌)中的异常高表达，并证明其通过调控镁离子内流促进肿瘤增殖。

3. **文献名称**：*Structural insights into MMGT1-antibody interactions using cryo-EM*

**作者**：Tanaka K, et al.

**摘要**：结合冷冻电镜技术及MMGT1抗体标记，解析了MMGT1蛋白的三维结构，阐明了其跨膜结构域在镁离子选择性转运中的分子机制。

4. **文献名称**：*MMGT1 antibody-based screening identifies its role in neuronal differentiation*

**作者**：Gupta R, et al.

**摘要**：利用MMGT1抗体进行免疫荧光筛选，发现该蛋白在神经元分化过程中动态表达，并参与调节神经突触的镁依赖性信号通路。

**提示**：实际研究中，建议通过PubMed或Google Scholar以关键词“MMGT1 antibody”或“MMGT1 function”检索最新文献，并优先选择高影响力期刊的论文。

       

背景信息

The MMGT1 (also known as EMC10) antibody targets the MMGT1 protein, a member of the ER membrane protein complex (EMC) involved in membrane protein biogenesis and lipid homeostasis. MMGT1 is ubiquitously expressed and plays a critical role in the insertion of transmembrane domains during the co-translational assembly of multi-pass membrane proteins. Dysregulation of MMGT1 has been linked to metabolic disorders, neurodevelopmental conditions, and cancer progression.

Antibodies against MMGT1 are essential tools for studying its expression, localization, and interaction partners. They are widely used in techniques like Western blotting, immunofluorescence, and co-immunoprecipitation to explore MMGT1’s role in cellular processes such as endoplasmic reticulum (ER) stress response, protein folding, and lipid metabolism. Recent studies highlight its potential as a biomarker in diseases like obesity and hepatocellular carcinoma.

MMGT1 antibodies are typically validated for specificity across human, mouse, and rat models, aiding cross-species research. Challenges include distinguishing MMGT1 from homologous EMC subunits due to structural similarities, requiring rigorous validation. Ongoing research focuses on elucidating its mechanistic contributions to disease pathways, positioning MMGT1 as a promising therapeutic target. These antibodies thus serve as vital reagents for both basic and translational studies in cell biology and pathology.

       
MMGT1抗体;MMGT1;MMGT1 Antibody;

公司简介

湖北瑞和宁生物科技有限公司研究创新能力， 拥有完整、科学、质量管理体系。并不断致力于技术创新，产品创新和管理创新，赢得了国内外广大用户的信任。

成立日期 (2年)
注册资本 50万(元)
员工人数 1-10人
年营业额 ￥ 100万以内
经营模式 贸易,工厂,试剂,定制,服务
主营行业 中间体,化学试剂

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