TBCA抗体

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     Gel: 12%SDS-PAGE, Lysate: 40 μg, Lane: Mouse adrenal gland tissue, Primary antibody: P02082(TBCA Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using P02082(TBCA Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P02082(TBCA Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

Tubulin-specific chaperone A (TBCA) is a critical protein involved in the folding and assembly of β-tubulin, a key component of microtubules. Microtubules are dynamic cytoskeletal structures essential for cell division, intracellular transport, and maintaining cell shape. TBCA, part of the tubulin chaperone system (including TBCB, TBCC, and TBCD), ensures proper β-tubulin folding by binding to nascent polypeptides, preventing aggregation, and facilitating their transfer to subsequent chaperones for heterodimerization with α-tubulin. This process is vital for functional microtubule formation.

Research on TBCA antibodies has grown due to their utility in studying tubulin biogenesis and microtubule-related pathologies. Antibodies targeting TBCA enable detection and quantification of the protein in cells, aiding investigations into its expression patterns, subcellular localization, and interactions. Dysregulation of TBCA is linked to neurodevelopmental disorders and cancer, as altered tubulin dynamics can disrupt mitosis or neuronal migration. For example, TBCA mutations are associated with encephalopathies and microcephaly, while its overexpression is observed in certain tumors.

TBCA antibodies are widely used in techniques like Western blotting, immunofluorescence, and co-immunoprecipitation, providing insights into microtubule assembly mechanisms and disease pathways. Their development underscores the importance of chaperone systems in cellular homeostasis and highlights potential therapeutic targets for microtubule-associated diseases.