FMO5抗体

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     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Human fetal liver and mouse lung tissue, Primary antibody: P02076(FMO5 Antibody) at dilution 1/250, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 seconds    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P02076(FMO5 Antibody) at dilution 1/30. (Original magnification: ×200)    

  
  

The flavin-containing monooxygenase 5 (FMO5) is a member of the FMO enzyme family, which plays a role in the oxidative metabolism of drugs, xenobiotics, and endogenous compounds. FMOs are NADPH-dependent enzymes that oxygenate nucleophilic heteroatoms (e.g., nitrogen, sulfur) in substrates. FMO5. encoded by the *FMO5* gene in humans, is primarily expressed in the liver and kidneys. Unlike other FMO isoforms (e.g., FMO1. FMO3), FMO5 exhibits distinct substrate specificity, preferring to metabolize compounds with sulfur-containing moieties or long-chain aliphatic amines. Its precise physiological role remains less understood compared to FMO3. which is critical in trimethylamine metabolism.

FMO5 antibodies are immunological tools used to detect and quantify FMO5 protein expression in research settings. These antibodies aid in studying FMO5's tissue distribution, regulatory mechanisms, and potential involvement in disease. For instance, altered FMO5 expression has been observed in certain cancers and metabolic disorders, though its clinical significance is still under investigation. Commercially available FMO5 antibodies are typically validated for applications like Western blotting, immunohistochemistry, or ELISA. Challenges in antibody development include ensuring specificity due to structural similarities among FMO isoforms. Recent studies also explore FMO5's role in aging and lipid metabolism, linking it to pathways like PPAR signaling. Overall, FMO5 antibodies remain essential for elucidating the enzyme's biological functions and therapeutic potential.