YY1AP1抗体

The YY1AP1 (YY1-associated protein 1) antibody is a tool used to study the YY1AP1 protein, a nuclear factor that interacts with the transcription factor YY1 (Yin Yang 1). YY1AP1 is implicated in regulating gene expression by modulating chromatin structure and epigenetic modifications. It plays a role in DNA repair, cell cycle progression, and cellular responses to stress. Dysregulation of YY1AP1 has been linked to cancer, particularly in pathways involving tumor suppression and oncogenesis, as well as developmental disorders. Researchers use the YY1AP1 antibody in techniques like Western blotting, immunoprecipitation, and immunofluorescence to detect protein expression, localization, and interaction partners. Commercial YY1AP1 antibodies are typically developed in hosts such as rabbits or mice, with validation data including specificity tests (e.g., siRNA knockdown or knockout cell lines) and cross-reactivity assessments. Its application spans studies in cancer biology, neurodevelopmental diseases, and mechanisms of transcriptional regulation. However, variability in antibody performance (e.g., batch differences or non-specific binding) requires careful experimental optimization. Recent studies highlight YY1AP1's potential as a biomarker or therapeutic target, driving demand for reliable antibodies in both basic and translational research contexts.