WSB1抗体

The WSB1 (WD Repeat and SOCS Box-Containing 1) antibody is a tool used to study the WSB1 protein, a member of the SOCS (Suppressor of Cytokine Signaling) box protein family. WSB1 contains WD40 repeats, which mediate protein-protein interactions, and a SOCS box domain that associates with Elongin B/C-Cullin complexes to form E3 ubiquitin ligases. This protein plays a role in ubiquitination, targeting substrates for proteasomal degradation. WSB1 is notably involved in hypoxia-related pathways by regulating the stability of hypoxia-inducible factor 1α (HIF-1α) through oxygen-dependent degradation. It has also been implicated in cancer progression, immune responses, and circadian rhythm regulation. Elevated WSB1 expression correlates with poor prognosis in certain cancers, suggesting its role in tumorigenesis and metastasis. The WSB1 antibody is essential for detecting protein expression levels, studying its interaction partners, and exploring its regulatory mechanisms in cellular processes. Researchers utilize it in techniques like Western blotting, immunoprecipitation, and immunohistochemistry to investigate WSB1's biological functions and therapeutic potential in diseases linked to ubiquitination dysregulation.