WDR18抗体

+ +

•  

   

     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Jurkat and PC-3 cell lysates, Primary antibody: P02020(WDR18 Antibody) at dilution 1/400, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute    

  
  

•  

   

     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P02020(WDR18 Antibody) at dilution 1/25. (Original magnification: ×200)    

  
  

•  

   

     The image is immunohistochemistry of paraffin-embedded Human lung cancer tissue using P02020(WDR18 Antibody) at dilution 1/25. (Original magnification: ×200)    

  
  

WDR18 (WD repeat domain 18) is a member of the WD40 repeat protein family, characterized by conserved repeats that facilitate protein-protein interactions and complex assembly. It is ubiquitously expressed and plays roles in ribosomal biogenesis, cell cycle regulation, and chromatin dynamics. WDR18 interacts with components of the PIK3C3 (phosphatidylinositol 3-kinase catalytic subunit type 3) complex and the UTP-C (U3 small nucleolar RNA-associated protein complex), linking it to autophagosome formation and pre-rRNA processing. Studies suggest its involvement in maintaining nucleolar structure and mitotic fidelity.

Antibodies targeting WDR18 are primarily used to study its expression, localization, and interactions in cellular pathways. Dysregulation of WDR18 has been implicated in cancers, neurodevelopmental disorders, and ciliopathies, though its precise mechanistic contributions remain under investigation. Researchers employ WDR18 antibodies in techniques like Western blotting, immunofluorescence, and co-immunoprecipitation to explore its role in cellular homeostasis and disease. Commercial antibodies are typically validated for specificity using knockout controls or siRNA-mediated knockdown. Despite its emerging significance, WDR18's full functional landscape and therapeutic potential require further elucidation.