VPS41抗体

+ +

•  

   

     Gel: 12%SDS-PAGE, Lysate: 40 μg, Lane: K562 cell lysate, Primary antibody: P10248(HBZ Antibody) at dilution 1/1600, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 10 seconds    

  
  

•  

   

     The image is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using P10248(HBZ Antibody) at dilution 1/120. (Original magnification: ×200)    

  
  

•  

   

     The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P10248(HBZ Antibody) at dilution 1/120. (Original magnification: ×200)    

  
  

VPS41 (Vacuolar Protein Sorting 41) is a critical component of the HOPS (Homotypic Fusion and Vacuole Protein Sorting) complex, which regulates membrane trafficking and fusion events in eukaryotic cells. It plays a key role in lysosome-related organelle biogenesis, endosomal-lysosomal transport, and autophagy by facilitating vesicle docking and fusion. Dysregulation of VPS41 is linked to neurodegenerative disorders like Parkinson’s and Alzheimer’s disease, as well as Hermansky-Pudlak syndrome, a genetic condition affecting lysosome function and pigmentation.

VPS41 antibodies are essential tools for studying these processes. They enable detection and localization of VPS41 in cells or tissues via techniques such as Western blotting, immunofluorescence, and immunoprecipitation. Researchers use these antibodies to investigate VPS41 expression levels, interactions with HOPS complex partners (e.g., VPS39. VPS18), and its role in pathological conditions. Polyclonal or monoclonal variants are typically raised in hosts like rabbits or mice, often validated for specificity using knockout controls.

Studies employing VPS41 antibodies have clarified its involvement in neuronal survival, melanosome maturation, and cellular responses to stress. Such insights highlight its potential as a therapeutic target for diseases linked to lysosomal dysfunction or impaired protein trafficking.