UGP2抗体

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     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Hela cell, Primary antibody: P01971(UGP2 Antibody) at dilution 1/500, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human breast cancer tissue using P01971(UGP2 Antibody) at dilution 1/35. (Original magnification: ×200)    

  
  

**Background of UGP2 Antibody**

UGP2 (UDP-glucose pyrophosphorylase 2) is a key enzyme involved in carbohydrate metabolism, catalyzing the reversible synthesis of UDP-glucose from glucose-1-phosphate and UTP. UDP-glucose serves as a critical precursor for glycogen synthesis, cell wall polysaccharides, and protein glycosylation, making UGP2 indispensable in energy storage and cellular homeostasis. While UGP1. a homologous isoform, is ubiquitously expressed, UGP2 exhibits tissue-specific expression, predominantly in the liver, muscle, and brain, suggesting distinct regulatory roles in glucose utilization and glycogen dynamics.

Antibodies targeting UGP2 are essential tools for studying its expression, localization, and function in metabolic pathways. They enable researchers to detect UGP2 protein levels via techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF), aiding in the exploration of its tissue distribution and regulatory mechanisms. Such antibodies are particularly valuable in metabolic disorder research, as dysregulation of UGP2 has been implicated in conditions like diabetes, glycogen storage diseases, and certain cancers characterized by altered glucose metabolism.

Furthermore, UGP2 antibodies contribute to elucidating the enzyme's role in stress responses and developmental processes, where UDP-glucose signaling intersects with pathways like ER stress and inflammatory signaling. By facilitating precise detection and functional analysis, UGP2 antibodies support advancements in understanding metabolic diseases and therapeutic targeting.

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