TPX2抗体

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     Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane 1-2: K562 cells, A431 cells, Primary antibody: P01927(TPX2 Antibody) at dilution 1/800, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 seconds    

  
  

The TPX2 (Targeting Protein for Xklp2) antibody is a key tool in studying the role of TPX2. a microtubule-associated protein critical for mitotic spindle assembly and cell cycle regulation. Discovered in the late 1990s, TPX2 is essential for activating Aurora A kinase, a driver of centrosome maturation and spindle formation. It localizes to the spindle apparatus during mitosis, facilitating microtubule nucleation and ensuring proper chromosome segregation. Dysregulation of TPX2 is linked to genomic instability and cancer progression, with overexpression observed in various malignancies, including breast, lung, and pancreatic cancers. This association makes TPX2 a potential biomarker and therapeutic target.

TPX2 antibodies are widely used in research to detect TPX2 expression and distribution via techniques like immunofluorescence, Western blotting, and immunohistochemistry. They help elucidate TPX2's involvement in mitotic errors, tumorigenesis, and response to anti-mitotic therapies. Commercial TPX2 antibodies are typically raised against specific epitopes, often in rabbit or mouse hosts, and validated for specificity across human and model organisms. Recent studies also explore TPX2's non-mitotic roles, such as in neuronal development or DNA repair, broadening its biological significance. As cancer research advances, TPX2 antibodies remain vital for unraveling mechanisms of cell division and developing targeted oncology treatments.