TMPRSS4抗体

+ +

•  

   

     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: A431 cells, Primary antibody: P01915(TMPRSS4 Antibody) at dilution 1/500, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 3 minutes    

  
  

•  

   

     The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P01915(TMPRSS4 Antibody) at dilution 1/45. (Original magnification: ×200)    

  
  

The TMPRSS4 (Transmembrane Serine Protease 4) antibody is a tool used to detect and study the TMPRSS4 protein, a member of the type II transmembrane serine protease (TTSP) family. TMPRSS4 is characterized by a transmembrane domain, a cytoplasmic region, and an extracellular serine protease domain. It plays roles in cellular processes such as epithelial integrity, ion channel regulation, and extracellular matrix remodeling. Research has highlighted its overexpression in multiple cancers, including pancreatic, lung, thyroid, and colorectal cancers, where it promotes tumor progression, metastasis, and resistance to therapy. Its oncogenic effects are linked to activation of pathways like EMT (epithelial-mesenchymal transition), integrin signaling, and proteolytic processing of substrates such as pro-urokinase plasminogen activator (pro-uPA).

TMPRSS4 antibodies are primarily utilized in research to investigate its expression patterns, functional mechanisms, and clinical relevance. These antibodies enable detection via techniques like Western blotting, immunohistochemistry, and flow cytometry. Studies using TMPRSS4 antibodies have identified its potential as a diagnostic or prognostic biomarker in cancer. Additionally, therapeutic strategies targeting TMPRSS4. including inhibitory antibodies or small molecules, are under exploration to block its protease activity or disrupt its interaction with downstream effectors. However, challenges remain in understanding its precise regulatory networks and validating its therapeutic utility in vivo. Overall, TMPRSS4 antibodies serve as critical reagents in unraveling the biology of this protease and its implications in disease.