FUS抗体

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     Western blot analysis of HLA-DQA1 expression in human spleen lysate.    

  
  

FUS (Fused in Sarcoma) antibodies are essential tools in studying the FUS protein, a multifunctional RNA-binding protein encoded by the *FUS* gene. FUS belongs to the TET family of proteins involved in RNA metabolism, including transcription, splicing, transport, and stability. It plays critical roles in neuronal development, DNA repair, and stress response. Dysregulation of FUS is linked to neurodegenerative diseases, particularly amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD), where mutations or abnormal cytoplasmic accumulation of FUS are observed. Additionally, FUS is implicated in certain cancers, such as sarcomas, due to chromosomal translocations.

FUS antibodies are widely used in research to detect FUS expression, localization, and post-translational modifications. They enable techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to study pathological aggregates in ALS/FTLD patient tissues or cell models. Monoclonal and polyclonal antibodies targeting specific FUS epitopes help differentiate between normal nuclear FUS and mislocalized cytoplasmic forms. Validating antibody specificity is crucial, as cross-reactivity with related proteins (e.g., EWSR1 or TAF15) can lead to false interpretations. Recent studies also explore FUS's role in liquid-liquid phase separation and stress granule dynamics, further driving demand for high-quality antibodies. Overall, FUS antibodies are pivotal in unraveling the protein’s physiological functions and its contribution to disease mechanisms.