TBL1X抗体

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     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Human lung cancer and placenta tissue, Primary antibody: P01874(TBL1X Antibody) at dilution 1/500, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 5 seconds    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human breast cancer tissue using P01874(TBL1X Antibody) at dilution 1/30. (Original magnification: ×200)    

  
  

TBL1X (Transducin Beta-Like 1 X-Linked) is a protein encoded by the TBL1X gene, located on the X chromosome. It belongs to the WD40 repeat protein family, known for mediating protein-protein interactions. TBL1X is a core component of the nuclear receptor corepressor (N-CoR) and silencing mediator for retinoid and thyroid hormone receptors (SMRT) complexes, which regulate transcription by recruiting histone deacetylases (HDACs) to suppress gene expression. It plays a critical role in chromatin remodeling, transcriptional repression, and signal-dependent exchange of corepressors for coactivators during gene activation.

TBL1X antibodies are essential tools for studying its function in diverse biological processes, including embryonic development, cell differentiation, and metabolic regulation. Dysregulation of TBL1X is linked to diseases such as X-linked intellectual disability, sensorineural hearing loss, and cancers. In oncology, TBL1X overexpression has been associated with tumor progression, particularly in breast cancer and leukemia, where it modulates oncogenic pathways like Wnt/β-catenin and NF-κB.

Researchers use TBL1X antibodies in techniques like Western blotting, immunoprecipitation, immunofluorescence, and chromatin immunoprecipitation (ChIP) to investigate its localization, protein interactions, and DNA-binding dynamics. These antibodies help elucidate mechanisms underlying TBL1X-associated pathologies and potential therapeutic targets. Specificity validation via knockout controls is critical due to homology with its paralog TBL1XR1.