SYTL5抗体

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     The image is immunohistochemistry of paraffin-embedded Human brain tissue using P01859(SYTL5 Antibody) at dilution 1/50. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P01859(SYTL5 Antibody) at dilution 1/50. (Original magnification: ×200)    

  
  

The SYTL5 antibody targets Synaptotagmin-like protein 5 (SYTL5), a member of the synaptotagmin-related protein family. SYTL5 contains characteristic C2 domains and a Rab-binding motif, suggesting roles in membrane trafficking and vesicle transport. It is primarily studied for its interaction with Rab GTPases, which regulate intracellular vesicle formation, motility, and fusion. SYTL5 is implicated in secretory pathways, particularly in specialized cell types like endocrine or immune cells, though its precise biological functions remain under investigation.

Research links SYTL5 to cancer progression, with studies noting its overexpression in certain tumors, potentially influencing cell invasion or metastasis. It has also been associated with neurological disorders, possibly due to disrupted vesicle dynamics in synaptic transmission.

SYTL5 antibodies are essential tools for detecting protein expression, localization, and interaction partners via techniques like Western blot, immunofluorescence, or co-immunoprecipitation. Validation often includes verifying reactivity in knockdown models or tissue-specific expression patterns. Commercial SYTL5 antibodies vary in host species, clonality, and conjugation, requiring careful selection based on experimental needs. Challenges include ensuring specificity due to homology within the synaptotagmin-like family. Ongoing studies aim to clarify SYTL5's mechanistic roles and therapeutic potential in disease contexts.