SSBP1抗体

+ +

•  

   

     The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P01840(SSBP1 Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

•  

   

     The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P01840(SSBP1 Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

SSBP1 (Single-Stranded DNA Binding Protein 1) is a critical protein involved in maintaining mitochondrial genome stability by binding to single-stranded DNA (ssDNA) during replication and repair. It functions as a tetramer, interacting with other mitochondrial enzymes like DNA polymerase γ and helicase TWINKLE to facilitate proper mtDNA synthesis. SSBP1 mutations are linked to human diseases, including autosomal dominant optic atrophy (ADOA) and early-onset mitochondrial disorders, highlighting its essential role in mitochondrial function.

Antibodies targeting SSBP1 are vital tools in studying its expression, localization, and molecular interactions. They are widely used in techniques like Western blotting, immunofluorescence, and immunoprecipitation to investigate SSBP1's involvement in mitochondrial DNA maintenance, cellular stress responses, and disease mechanisms. Commercial SSBP1 antibodies are typically raised in hosts such as rabbits or mice, with validation in knockdown models or SSBP1-deficient cells to ensure specificity. Researchers rely on these antibodies to explore SSBP1's regulatory roles in metabolic pathways, aging, and pathologies like cancer or neurodegenerative diseases, where mitochondrial dysfunction is implicated. Reliable SSBP1 detection aids in advancing understanding of mitochondrial biology and therapeutic targeting.