SENP5抗体

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     The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P01783(SENP5 Antibody) at dilution 1/140. (Original magnification: ×200)    

  
  

The SENP5 antibody is a research tool designed to detect and study Sentrin/SUMO-specific protease 5 (SENP5), a member of the SENP family of proteases. SENP enzymes regulate SUMO (Small Ubiquitin-like Modifier) post-translational modifications by cleaving precursor SUMO proteins to their mature forms or removing SUMO conjugates from target proteins. This dynamic process, termed SUMOylation, plays critical roles in cellular functions such as nuclear-cytoplasmic transport, chromatin remodeling, DNA repair, and stress responses. SENP5. localized predominantly in the nucleolus and mitochondria, is implicated in ribosome biogenesis, mitochondrial dynamics, and apoptosis. Dysregulation of SENP5 has been linked to diseases, including cancer and neurodegenerative disorders, underscoring its biological relevance.

SENP5 antibodies are typically generated in immunized hosts (e.g., rabbits or mice) using antigenic regions of the SENP5 protein, such as specific peptide sequences or recombinant fragments. These antibodies are validated for applications like Western blotting, immunofluorescence, and immunoprecipitation to assess SENP5 expression, localization, and interactions. Specificity is confirmed using knockout cell lines or siRNA-mediated knockdown controls. Researchers employ SENP5 antibodies to investigate its role in modulating SUMOylation dynamics under physiological or pathological conditions, such as cellular stress, tumorigenesis, or mitochondrial dysfunction. Their utility extends to mechanistic studies exploring how SENP5-mediated deSUMOylation impacts signaling pathways, genomic stability, and organelle function, offering insights into therapeutic targeting opportunities.