RRAGC抗体

RRAGC (Ras-related GTP-binding protein C) is a critical subunit of the Rag GTPase heterodimer, which plays a central role in nutrient-sensing signaling pathways, particularly the mTORC1 (mechanistic target of rapamycin complex 1) pathway. As a member of the Rag family (RagA/B/C/D), RRAGC forms obligate heterodimers with RagA or RagB, functioning as a molecular switch that cycles between GTP- and GDP-bound states. This cycling enables RRAGC to sense cellular amino acid availability and recruit mTORC1 to lysosomal surfaces for activation, thereby regulating cell growth, metabolism, and autophagy. Dysregulation of RRAGC or its interacting partners is linked to metabolic disorders, cancer, and neurodegenerative diseases. Antibodies targeting RRAGC are essential tools for studying its expression, localization, and post-translational modifications in various biological contexts. They are widely used in techniques like Western blotting, immunofluorescence, and immunoprecipitation to investigate mTORC1 pathway dynamics, nutrient responses, and disease mechanisms. Specific RRAGC antibodies also aid in distinguishing between active (GTP-bound) and inactive (GDP-bound) conformations, providing insights into its regulatory roles in health and disease.