RGS14抗体

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     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Jurkat cell lysate, Primary antibody: P01726(RGS14 Antibody) at dilution 1/1000, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 1 minute    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using P01726(RGS14 Antibody) at dilution 1/160. (Original magnification: ×200)    

  
  

RGS14 (Regulator of G-protein Signaling 14) is a multifunctional scaffolding protein highly expressed in the brain, particularly in hippocampal pyramidal neurons. It modulates G-protein-coupled receptor (GPCR) signaling by interacting with Gαi/o subunits to accelerate GTP hydrolysis, thereby terminating downstream signaling. Beyond its canonical role in GPCR regulation, RGS14 integrates multiple signaling pathways, including the MAP kinase cascade and calcium/calmodulin-dependent kinase II (CaMKII), influencing synaptic plasticity, learning, and memory. Studies highlight its unique ability to suppress long-term potentiation (LTP) while promoting long-term depression (LTD), suggesting a critical role in balancing excitatory synaptic transmission. RGS14 knockout mice exhibit enhanced hippocampal-dependent learning, implicating its physiological function in cognitive processes.

RGS14 antibodies are essential tools for investigating its expression, localization, and molecular interactions. These antibodies enable detection of RGS14 in brain tissues and cultured cells via techniques like Western blot, immunohistochemistry, and immunoprecipitation. Species-specific monoclonal and polyclonal antibodies have been developed, validated for cross-reactivity in humans, mice, and rats. Research applications include exploring RGS14's involvement in neurological disorders, such as epilepsy, Alzheimer’s disease, and schizophrenia, where dysregulated synaptic plasticity is implicated. Recent studies also examine its potential role in cancer and cardiovascular diseases due to its signaling modulation properties. Reliable RGS14 antibodies are critical for dissecting its dual roles as a GPCR regulator and a synaptic plasticity suppressor in health and disease.