RGS1抗体

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     Gel: 12%SDS-PAGE, Lysate: 40 μg, Lane: RAW264.7 cells, Primary antibody: P01722(RGS1 Antibody) at dilution 1/400, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 2 minutes    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using P01722(RGS1 Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

The Regulator of G-protein Signaling 1 (RGS1) protein is a member of the RGS family, which plays a critical role in regulating G-protein-coupled receptor (GPCR) signaling pathways. RGS proteins act as GTPase-activating proteins (GAPs) for Gα subunits, accelerating the hydrolysis of GTP to terminate signaling. RGS1 specifically interacts with Gαi/o subunits, modulating cellular responses to neurotransmitters, hormones, and chemokines. It is highly expressed in immune cells, including B cells, T cells, and dendritic cells, where it influences cell migration, immune activation, and inflammatory responses. Dysregulation of RGS1 has been implicated in autoimmune diseases, neuropathologies, and cancers, making it a potential therapeutic target.

RGS1 antibodies are essential tools for studying its expression, localization, and function. These antibodies enable detection via techniques like Western blotting, immunohistochemistry, and flow cytometry. Polyclonal antibodies recognize multiple epitopes, offering high sensitivity, while monoclonal antibodies provide specificity for targeted research. Applications include investigating RGS1's role in immune cell trafficking, GPCR signal termination, and disease mechanisms. Recent studies highlight its involvement in cancer metastasis and autoimmune disorders like multiple sclerosis, driving interest in RGS1-targeted diagnostics and therapies. Validated antibodies are crucial for ensuring reproducibility in both basic research and drug development contexts.