RASAL1抗体

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     The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P01702(RASAL1 Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P01702(RASAL1 Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

The RASAL1 antibody targets the Ras GTPase-activating protein (RasGAP) RASAL1. a critical regulator of Ras signaling pathways. RASAL1 functions as a tumor suppressor by modulating Ras activity through its GTPase-activating domain, which accelerates the conversion of active GTP-bound Ras to its inactive GDP-bound state, thereby inhibiting downstream signaling involved in cell proliferation, survival, and differentiation. Dysregulation of RASAL1. often due to promoter hypermethylation or genetic mutations, has been implicated in various cancers, including colorectal, ovarian, and renal carcinomas, where its loss correlates with increased Ras-driven oncogenesis.

RASAL1 antibodies are essential tools for studying its expression, localization, and functional roles in both normal and pathological conditions. They are widely used in techniques such as Western blotting, immunohistochemistry, and immunofluorescence to assess protein levels in tissues or cell lines. Research utilizing these antibodies has revealed RASAL1's involvement in maintaining cellular homeostasis, suppressing fibrosis, and regulating metabolic processes. Additionally, studies highlight its potential as a biomarker for disease prognosis or therapeutic targeting.

The development and validation of high-specificity RASAL1 antibodies remain crucial for advancing understanding of Ras signaling dynamics and exploring therapeutic strategies to restore RASAL1 function in cancers and other Ras-related disorders.