PTPN5抗体

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     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P01683(PTPN5 Antibody) at dilution 1/30. (Original magnification: ×200)    

  
  

PTPN5 (Protein Tyrosine Phosphatase Non-Receptor Type 5), also known as STEP (Striatal-Enriched Protein Tyrosine Phosphatase), is a brain-specific phosphatase that regulates synaptic signaling and plasticity by dephosphorylating key neuronal substrates, including kinases (e.g., ERK1/2. Fyn) and glutamate receptor subunits. It plays a critical role in modulating synaptic strength, learning, and memory. Dysregulation of PTPN5 has been implicated in neurological disorders such as Alzheimer’s disease, schizophrenia, and Parkinson’s disease.

Antibodies targeting PTPN5 are essential tools for studying its expression, localization, and function in neural tissues. These antibodies are commonly used in techniques like Western blotting, immunohistochemistry, and immunoprecipitation to investigate PTPN5’s role in synaptic pathways and disease mechanisms. High-quality PTPN5 antibodies exhibit specificity for distinct isoforms (e.g., STEP46. STEP61) and are validated in knockout models or phosphatase-deficient cells to ensure target selectivity.

Research applications often focus on PTPN5’s interaction with postsynaptic density proteins and its inhibition of NMDA receptor trafficking. Commercial PTPN5 antibodies are typically raised against epitopes within its N-terminal catalytic domain or C-terminal regulatory regions. Reliable antibodies enable insights into how PTPN5 activity influences neurodevelopmental and neurodegenerative processes, supporting therapeutic exploration for brain disorders.