RMDN3抗体

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     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Mouse kidney tissue, Primary antibody: P01677(RMDN3 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 5 minutes    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human breast cancer tissue using P01677(RMDN3 Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P01677(RMDN3 Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

The RMDN3 (Regulating Mitochondrial Dynamics and Neurodegeneration 3) antibody is a tool used to study the RMDN3 protein, which plays a role in mitochondrial dynamics and cellular homeostasis. RMDN3. also known as CHCHD3 (Coiled-Coil-Helix-Coiled-Coil-Helix Domain Containing 3), is implicated in maintaining mitochondrial cristae structure and function, impacting energy production, apoptosis, and stress responses. Dysregulation of RMDN3 has been linked to neurodegenerative diseases, such as Parkinson’s and Alzheimer’s, due to its involvement in mitochondrial quality control and neuronal survival.

The RMDN3 antibody is primarily employed in research applications like Western blotting, immunofluorescence, and immunohistochemistry to detect protein expression levels, localization, and interactions. It aids in exploring how RMDN3 modulates mitochondrial morphology, fusion-fission balance, and cross-talk with other organelles like the endoplasmic reticulum. Studies using this antibody have highlighted its relevance in cancer biology, where mitochondrial dysfunction contributes to tumor progression and therapy resistance. Additionally, it supports investigations into aging-related disorders and metabolic syndromes tied to mitochondrial impairment. Validated for specificity in human and rodent models, the RMDN3 antibody remains critical for deciphering mitochondrial mechanisms in health and disease.