SERPINB2抗体

+ +

•  

   

     The image is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using P01621(SERPINB2 Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

SERPINB2. also known as plasminogen activator inhibitor type 2 (PAI-2), is a member of the serine protease inhibitor (serpin) superfamily. It is primarily expressed in placental tissues, keratinocytes, and immune cells, functioning as a regulator of extracellular matrix remodeling, cell migration, and inflammation by inhibiting urokinase-type plasminogen activator (uPA) and tissue-type plasminogen activator (tPA). SERPINB2 is implicated in diverse physiological and pathological processes, including cancer progression, thrombotic disorders, skin barrier maintenance, and immune responses. Its expression is often upregulated under stress conditions, such as hypoxia or cytokine stimulation.

SERPINB2 antibodies are essential tools for studying its biological roles and disease associations. These antibodies are widely used in techniques like Western blotting, immunohistochemistry, and ELISA to detect SERPINB2 expression levels, cellular localization, and interactions in various tissues or disease models. Both monoclonal and polyclonal antibodies are available, with specificity validated through knockdown controls or blocking peptides. Researchers utilize these antibodies to explore SERPINB2's dual roles—acting as a tumor suppressor in some cancers while promoting cell survival in others—and its potential as a biomarker for inflammatory or thrombotic diseases. Recent studies also focus on its non-inhibitory functions, including immunomodulation and intracellular signaling, expanding its relevance in biomedical research.