OCIAD2抗体

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     Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane: A172 cells, Primary antibody: P01611(OCIAD2 Antibody) at dilution 1/250, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 minutes    

  
  

The OCIAD2 (Ovarian Carcinoma Immunoreactive Antigen Domain Containing 2) gene encodes a mitochondrial membrane-associated protein implicated in cellular energy metabolism and mitochondrial function. Initially identified in ovarian cancer studies, OCIAD2 is broadly expressed across tissues and localizes to mitochondrion-associated membranes (MAMs), critical sites for regulating lipid metabolism, calcium signaling, and apoptosis. Its role in mitochondrial dynamics and inter-organelle communication suggests involvement in cellular stress responses and homeostasis.

OCIAD2 has been linked to cancer progression, particularly in ovarian, lung, and colorectal cancers, where overexpression correlates with tumor aggressiveness, metastasis, and poor prognosis. It may promote survival pathways by modulating mitochondrial apoptosis or interacting with oncogenic signaling networks. Recent studies also highlight its potential association with neurodegenerative disorders, such as Alzheimer’s disease, possibly through mitochondrial dysfunction.

Antibodies targeting OCIAD2 are essential tools for detecting its expression and localization in cells or tissues. They enable research into its molecular mechanisms, diagnostic applications, and therapeutic targeting. However, challenges remain in validating antibody specificity due to OCIAD2’s structural homology with OCIAD1 and cross-reactivity risks. Ongoing studies aim to clarify its dual roles in cancer and neurodegeneration, positioning OCIAD2 as a multifaceted protein with translational research significance.