NECTIN3抗体

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     Western blot analysis using human JCHAIN mouse mAb against  human plasma lysate    

  
  

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     IHC-P analysis of tonsil tissue by JCHAIN antibody (P154999) IHC-P was performed using sections of the formalin-fixed paraffin-embedded tonsil tissue;Result: Germinal center cells, non-germinal center cells and squamous epithelial cells are positively stained at the cytoplasm (Only positively stained Germinal center cells are shown here).    

  
  

Nectin-3. a member of the Nectin family of cell adhesion molecules, plays a critical role in mediating cell-cell adhesion and signaling. As part of the immunoglobulin superfamily, it contains three extracellular immunoglobulin-like domains that facilitate homophilic or heterophilic interactions, notably with Nectin-1. These interactions are essential for forming adherens junctions and tight junctions, often cooperating with cadherins and afadin to regulate tissue architecture, polarity, and morphogenesis. Nectin-3 is widely expressed in epithelial, neuronal, and immune cells, contributing to processes like synaptic plasticity, immune response modulation, and pathogen entry (e.g., herpesviruses).

Nectin-3 antibodies are immunological tools designed to detect, quantify, or inhibit this protein in research and clinical settings. They are commonly used in techniques such as Western blotting, immunohistochemistry, and flow cytometry to study Nectin-3's expression patterns and localization. Dysregulation of Nectin-3 has been implicated in pathologies, including cancer, neurological disorders, and infertility. For instance, reduced Nectin-3 expression correlates with poor prognosis in ovarian and lung cancers, while its overexpression may enhance tumor invasiveness. Antibodies targeting Nectin-3 also hold therapeutic potential, such as blocking viral entry or modulating immune checkpoints.

These antibodies are typically validated for specificity, sensitivity, and cross-reactivity across species. Both monoclonal and polyclonal variants are available, with applications spanning basic research to drug development. Ongoing studies explore their utility in biomarker discovery and targeted therapies, underscoring Nectin-3's multifaceted role in health and disease.