MTFR1抗体

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     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-3: A549 cells, HT29 cells, A172 cells, Primary antibody: P01562(MTFR1 Antibody) at dilution 1/500, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 5 seconds    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P01562(MTFR1 Antibody) at dilution 1/40. (Original magnification: ×200)    

  
  

**Background of MTFR1 Antibody**

MTFR1 (Mitochondrial Fission Regulator 1), also known as CHCHD3. is a mitochondrial protein critical for regulating mitochondrial dynamics, particularly fission. It localizes to the mitochondrial inner membrane and interacts with components of the mitochondrial contact site and cristae organizing system (MICOS), maintaining cristae structure and mitochondrial integrity. MTFR1 facilitates mitochondrial fission by recruiting the GTPase DRP1 to fission sites, a process essential for energy metabolism, apoptosis, and cellular adaptation to stress.

Antibodies targeting MTFR1 are vital tools for studying mitochondrial morphology, cellular stress responses, and diseases linked to mitochondrial dysfunction, such as cancer, neurodegenerative disorders, and metabolic syndromes. MTFR1 dysregulation has been implicated in tumor progression, where altered expression correlates with metastasis and chemoresistance. In neuroscience, MTFR1 variants are associated with Parkinson’s disease, highlighting its role in neuronal survival.

MTFR1 antibodies are widely used in techniques like Western blotting, immunofluorescence, and immunohistochemistry to assess protein expression, subcellular localization, and interactions. They enable researchers to explore MTFR1's functional mechanisms in mitochondrial dynamics and its potential as a therapeutic target. Validated antibodies ensure specificity across human, mouse, and rat models, supporting translational research in diverse pathological contexts.