MAGEB10抗体

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     The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P01529(MAGEB10 Antibody) at dilution 1/60. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human brain  tissue using P01529(MAGEB10 Antibody) at dilution 1/60. (Original magnification: ×200)    

  
  

The MAGEB10 antibody targets the melanoma-associated antigen B10 (MAGEB10), a member of the MAGE (Melanoma Antigen Gene) family. MAGE proteins are cancer-testis antigens normally expressed in germ cells but aberrantly reactivated in various cancers. MAGEB10. located on the X chromosome, is implicated in tumorigenesis, though its precise biological role remains under investigation. Studies suggest it may regulate transcription, cell cycle progression, or apoptosis evasion, contributing to cancer progression.

MAGEB10 overexpression has been observed in malignancies like melanoma, lung cancer, and hepatocellular carcinoma, correlating with poor prognosis and therapeutic resistance. Its restricted expression in healthy tissues (primarily testes) makes it a potential target for immunotherapy. Antibodies against MAGEB10 are critical tools for detecting its expression in tumor samples via techniques like immunohistochemistry (IHC) or Western blot (WB), aiding cancer diagnosis and biomarker studies. They also support functional research, such as elucidating interactions with proteins like E3 ubiquitin ligases or histones.

Therapeutic applications are being explored, including MAGEB10-specific monoclonal antibodies or CAR-T cells. However, challenges like off-target effects due to MAGE family homology and limited clinical validation hinder progress. Ongoing research focuses on refining antibody specificity and understanding MAGEB10's role in cancer biology to advance diagnostic and immunotherapeutic strategies.