ACP6抗体

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     The image is immunohistochemistry of paraffin-embedded Human gasrtic cancer tissue using P01518(ACP6 Antibody) at dilution 1/50. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using P01518(ACP6 Antibody) at dilution 1/50. (Original magnification: ×200)    

  
  

The ACP6 antibody targets the enzyme acid phosphatase 6 (ACP6), a member of the histidine acid phosphatase family. ACP6. encoded by the ACP6 gene in humans, is a lysosomal phosphatase involved in hydrolyzing phosphate groups from various substrates, playing a role in cellular metabolism and signaling. Structurally, it contains conserved active-site motifs critical for its catalytic activity. Research suggests ACP6 may regulate lipid metabolism, particularly in modulating lysophosphatidic acid (LPA) and sphingosine-1-phosphate (S1P) levels, which are key signaling molecules influencing cell proliferation, migration, and survival.

ACP6 antibodies are primarily used in research to detect and quantify ACP6 expression in tissues or cells, aiding studies on its physiological and pathological roles. Dysregulation of ACP6 has been implicated in cancers, metabolic disorders, and lysosomal storage diseases. For example, elevated ACP6 levels have been observed in certain tumors, potentially linked to aberrant lipid signaling pathways. Additionally, mutations in ACP6 may correlate with rare genetic disorders affecting lysosomal function.

As a tool, ACP6 antibodies enable insights into enzyme localization, activity, and interaction networks via techniques like Western blot, immunohistochemistry, or immunofluorescence. Ongoing studies aim to clarify its precise mechanisms and therapeutic potential in disease contexts.