LDHD抗体

The LDHD antibody is a research tool targeting lactate dehydrogenase D (LDHD), a lesser-studied isoform of the lactate dehydrogenase (LDH) enzyme family. LDH enzymes catalyze the interconversion of pyruvate and lactate, playing a central role in anaerobic glycolysis. While LDHA and LDHB are well-characterized in mammals, LDHD is evolutionarily distinct, sharing homology with archaeal LDHs, and is encoded by the *LDHD* gene on human chromosome 16. Unlike other isoforms, LDHD may exhibit unique substrate preferences or regulatory mechanisms, though its precise physiological role remains under investigation. LDHD expression has been detected in specific tissues, including the liver and kidneys, suggesting potential roles in organ-specific metabolic processes. Research interest in LDHD has grown due to its possible links to metabolic disorders, cancer, and mitochondrial dysfunction. The LDHD antibody enables detection and quantification of the enzyme in various applications, such as Western blotting, immunohistochemistry, and ELISA, aiding studies on its expression patterns and functional contributions. Recent studies also explore LDHD's involvement in lactate homeostasis and its implications in diseases characterized by altered metabolism. However, further validation is required to fully elucidate its biological significance and therapeutic potential.