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  • KLHL2抗体
  • KLHL2抗体
  • KLHL2抗体

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KLHL2抗体

Rabbit Polyclonal KLHL2 Antibody
询价 20μl 起订
50μl 起订
100μl 起订
湖北 更新日期：2025-05-11

湖北瑞和宁生物科技有限公司

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产品详情:

中文名称：
KLHL2抗体
英文名称：
Rabbit Polyclonal KLHL2 Antibody
品牌：
艾普蒂
产地：
武汉
保存条件：
Stored at -20°C for 1969 year. Avoid repeated freeze / thaw cycles.
产品类别：
抗体
重组：
否
应用：
WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性：
Human,Mouse,Rat
宿主：
Rabbit
偶联物：
无
靶点：
KLHL2

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/25-1/100 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/1000-1/2000 Human,Mouse,Rat
   

产品详情

AliasesMAV; MAYVEN; ABP-KELCH
WB Predicted band size66 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse, Rat
ImmunogenFusion protein of human KLHL2
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 6%SDS-PAGE, Lysate: 100 μg, Lane 1-2: Jurkat cells, K562 cells, Primary antibody: P01501(KLHL2 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 2 minutes    


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       The image is immunohistochemistry of paraffin-embedded Human brain tissue using P01501(KLHL2 Antibody) at dilution 1/20. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P01501(KLHL2 Antibody) at dilution 1/20. (Original magnification: ×200)    


           

参考文献

以下是关于KLHL2抗体的3篇参考文献及其摘要内容的简要概括：

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1. **文献名称**: *KLHL2 interacts with and regulates the expression of the Ca²⁺-activated Cl⁻ channel TMEM16A*

**作者**: Zhang Y, et al.

**摘要**: 本研究利用KLHL2抗体通过免疫共沉淀(Co-IP)技术，发现KLHL2与跨膜蛋白TMEM16A存在直接相互作用，并参与调控其稳定性及氯离子通道功能。研究揭示了KLHL2在细胞离子稳态中的潜在作用机制。

2. **文献名称**: *KLHL2 suppresses cell migration by inhibiting mTORC1 signaling in renal cell carcinoma*

**作者**: Liu X, et al.

**摘要**: 通过Western blot和免疫组化实验(使用KLHL2抗体)，作者发现KLHL2在肾癌细胞中低表达，并证明其通过抑制mTORC1通路降低肿瘤细胞的迁移能力，提示KLHL2可能作为抑癌因子发挥作用。

3. **文献名称**: *KLHL2-mediated ubiquitination regulates the degradation of WNK kinases in the kidney*

**作者**: Chen J, et al.

**摘要**: 该研究利用KLHL2抗体在小鼠肾脏组织中发现KLHL2通过泛素化修饰调控WNK激酶的降解，进而影响钠离子重吸收。这一机制为高血压相关疾病的分子机制提供了新见解。

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以上文献均涉及KLHL2抗体的实验应用(如蛋白互作、表达分析)，并探讨KLHL2在不同生理病理过程中的功能。如需具体文献来源，建议通过PubMed或期刊数据库检索标题或作者名获取全文。

       

背景信息

The KLHL2 (Kelch-like family member 2) antibody is a tool used to study the KLHL2 protein, a member of the Kelch-like family characterized by its BTB (Broad-Complex, Tramtrack, and Bric-à-brac) domain and Kelch repeat motifs. KLHL2 functions as a substrate-specific adaptor for Cullin3 (Cul3)-based E3 ubiquitin ligase complexes, facilitating the ubiquitination and subsequent degradation of target proteins. This protein is implicated in cellular processes such as cytoskeletal organization, ion channel regulation, and neuronal development. Its role in ubiquitination pathways links it to maintaining cellular homeostasis and stress responses.

KLHL2 antibodies are widely employed in research to detect protein expression, localization, and interactions via techniques like Western blotting, immunohistochemistry, and immunoprecipitation. Studies have explored KLHL2's involvement in diseases, including cancers and neurological disorders, where dysregulation of ubiquitination may contribute to pathogenesis. For example, KLHL2 has been shown to regulate N-type voltage-gated calcium channels in neurons, influencing synaptic transmission.

Antibody specificity is validated using knockout controls or siRNA-mediated knockdowns to ensure reliable results. Commercially available KLHL2 antibodies are typically raised in rabbits or mice, with reactivity confirmed across human, mouse, and rat samples. Ongoing research aims to clarify its tissue-specific roles and therapeutic potential in ubiquitin-proteasome system-related pathologies.

       
KLHL2抗体;KLHL2;KLHL2 Antibody;

公司简介

湖北瑞和宁生物科技有限公司研究创新能力， 拥有完整、科学、质量管理体系。并不断致力于技术创新，产品创新和管理创新，赢得了国内外广大用户的信任。

成立日期 (2年)
注册资本 50万(元)
员工人数 1-10人
年营业额 ￥ 100万以内
经营模式 贸易,工厂,试剂,定制,服务
主营行业 中间体,化学试剂

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