KDM4D抗体

The KDM4D antibody is a tool used to detect and study the KDM4D protein, a member of the lysine demethylase (KDM) family. KDM4D, also known as JMJD2D, is an enzyme that catalyzes the removal of methyl groups from histone H3 on lysine residues (e.g., H3K9me3/me2), playing a critical role in epigenetic regulation. It belongs to the Jumonji C (JmjC) domain-containing protein family and relies on α-ketoglutarate and Fe²⁺ as cofactors for its enzymatic activity. KDM4D is involved in chromatin remodeling, transcriptional regulation, and genome stability, impacting processes like DNA repair, cell cycle progression, and stem cell differentiation. Dysregulation of KDM4D has been linked to cancers, neurodegenerative disorders, and developmental abnormalities. Researchers use KDM4D antibodies in techniques like Western blotting, immunofluorescence, and chromatin immunoprecipitation (ChIP) to investigate its expression, localization, and interactions in various biological contexts. These antibodies are essential for exploring KDM4D’s role in disease mechanisms and evaluating its potential as a therapeutic target, particularly in oncology where epigenetic modifiers are gaining attention.