HSD17B6抗体

+ +

•  

   

     Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane: Mouse liver tissue, Primary antibody: P01454(HSD17B6 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute    

  
  

•  

   

     The image is immunohistochemistry of paraffin-embedded Human colon cancer tissue using P01454(HSD17B6 Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

The HSD17B6 antibody is a tool used to detect and study the hydroxysteroid 17-beta dehydrogenase 6 (HSD17B6) enzyme, which belongs to the 17β-hydroxysteroid dehydrogenase (17β-HSD) family. This enzyme plays a role in steroid metabolism, particularly in the conversion of inactive steroid precursors to active forms. HSD17B6 is involved in androgen biosynthesis, catalyzing reactions such as the conversion of androstanediol to dihydrotestosterone (DHT) and participating in retinol metabolism. Its expression is observed in tissues like the liver, prostate, and testes, linking it to hormonal regulation and metabolic pathways.

Researchers utilize HSD17B6 antibodies in techniques like Western blotting, immunohistochemistry, and immunofluorescence to investigate the enzyme's localization, expression levels, and role in physiological or pathological processes. Studies focus on its implications in hormone-dependent cancers (e.g., prostate cancer), endocrine disorders, and metabolic diseases. The antibody aids in understanding how HSD17B6 influences steroid hormone balance, cellular proliferation, and disease progression. Additionally, HSD17B6's interaction with lipid metabolism and bile acid synthesis has sparked interest in its broader metabolic functions. Validating antibody specificity is critical to ensure accurate detection, given the structural similarities among 17β-HSD family members. Overall, the HSD17B6 antibody serves as a key reagent in exploring steroid biology and its clinical associations.