HSD17B14抗体

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     Gel: 12%SDS-PAGE, Lysate: 40 μg, Lane: Mouse eye tissue lysate, Primary antibody: P01453(HSD17B14 Antibody) at dilution 1/600, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 20 seconds    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P01453(HSD17B14 Antibody) at dilution 1/70. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P01453(HSD17B14 Antibody) at dilution 1/70. (Original magnification: ×200)    

  
  

The HSD17B14 antibody is a research tool designed to detect and analyze the 17β-hydroxysteroid dehydrogenase type 14 (HSD17B14) protein, a member of the 17β-HSD enzyme family. These enzymes play critical roles in steroid hormone metabolism, particularly in the regulation of active and inactive forms of sex hormones (e.g., estrogens, androgens) and other steroids. HSD17B14 is implicated in converting estrone to estradiol and may influence hormonal balance in tissues. Structurally, it contains a conserved short-chain dehydrogenase/reductase (SDR) domain, typical of this enzyme family.

HSD17B14 antibodies are commonly used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to study the protein's expression, localization, and function in cellular or tissue samples. Research suggests HSD17B14 may have roles in hormone-dependent cancers (e.g., breast, prostate) and metabolic disorders, though its precise biological mechanisms remain under investigation. Antibodies against HSD17B14 help researchers explore its potential as a biomarker or therapeutic target. Commercial antibodies are often validated for specificity across human and model organism samples. Ongoing studies aim to clarify its physiological impact, interactions, and relevance to diseases, driving demand for reliable detection tools in both basic and translational research.