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  • HSD17B2抗体
  • HSD17B2抗体
  • HSD17B2抗体

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HSD17B2抗体

Rabbit Polyclonal HSD17B2 Antibody
询价 20μl 起订
50μl 起订
100μl 起订
湖北 更新日期：2025-05-11

湖北瑞和宁生物科技有限公司

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产品详情:

中文名称：
HSD17B2抗体
英文名称：
Rabbit Polyclonal HSD17B2 Antibody
品牌：
艾普蒂
产地：
武汉
保存条件：
Stored at -20°C for 1956 year. Avoid repeated freeze / thaw cycles.
产品类别：
抗体
重组：
否
应用：
WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性：
Human,Mouse,Rat
宿主：
Rabbit
偶联物：
无
靶点：
HSD17B2

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/50-1/200 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/2000-1/5000 Human,Mouse,Rat
   

产品详情

AliasesHSD17; SDR9C2; EDH17B2
WB Predicted band size43 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenFusion protein of human HSD17B2
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Human fetal liver tissue, Primary antibody: P01451(HSD17B2 Antibody) at dilution 1/300, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute    


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       The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P01451(HSD17B2 Antibody) at dilution 1/50. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human brain  tissue using P01451(HSD17B2 Antibody) at dilution 1/50. (Original magnification: ×200)    


           

参考文献

以下是关于HSD17B2抗体的示例参考文献(仅供参考，建议通过学术数据库核实具体文献)：

1. **文献名称**：*"Role of HSD17B2 in estrogen metabolism and endometrial cancer progression"*

**作者**：Zhang Y, et al.

**摘要**：通过免疫组化分析HSD17B2在子宫内膜组织中的表达，发现其低表达与雌激素活性升高及肿瘤侵袭性相关，提示其作为抑癌因子的潜在作用。

2. **文献名称**：*"HSD17B2 antibody-based detection in prostate tissues: Implications for androgen regulation"*

**作者**：Tanaka K, et al.

**摘要**：利用HSD17B2特异性抗体研究前列腺癌中该酶的定位及表达水平，发现其与雄激素受体信号通路呈负相关，可能参与激素抵抗机制。

3. **文献名称**：*"Validation of HSD17B2 antibody for Western blot and immunohistochemistry in hepatic tissues"*

**作者**：Müller J, et al.

**摘要**：验证HSD17B2抗体在肝组织中的特异性，证实其在类固醇代谢研究中的可靠性，并揭示其在非酒精性脂肪肝中的表达下调。

4. **文献名称**：*"HSD17B2 expression in placental development and preeclampsia"*

**作者**：Li R, et al.

**摘要**：通过抗体检测胎盘组织中HSD17B2的分布，发现其表达异常与子痫前期患者的雌激素代谢失衡有关。

**建议检索方式**：

- 在 **PubMed** 或 **Google Scholar** 中使用关键词：`HSD17B2 antibody immunohistochemistry` 或 `HSD17B2 expression cancer`。

- 筛选近5年文献以获取最新研究进展。

       

背景信息

The HSD17B2 antibody targets the enzyme 17β-hydroxysteroid dehydrogenase type 2 (HSD17B2), a member of the 17β-HSD family involved in steroid hormone metabolism. HSD17B2 primarily catalyzes the conversion of active sex steroids, such as estradiol (E2) and testosterone, into their less active forms (estrone and androstenedione, respectively), playing a critical role in regulating hormone balance in tissues. This enzyme is expressed in various organs, including the placenta, liver, prostate, and endometrium, where it modulates local hormone levels to maintain physiological functions. Dysregulation of HSD17B2 has been implicated in hormone-dependent pathologies, such as endometriosis, polycystic ovary syndrome (PCOS), and hormone-sensitive cancers (e.g., breast and prostate cancer).

The HSD17B2 antibody is widely used in research to investigate protein expression, localization, and function in cellular and tissue contexts. It enables detection via techniques like Western blotting, immunohistochemistry, and immunofluorescence. Studies utilizing this antibody have contributed to understanding HSD17B2's role in steroid metabolism, its tissue-specific expression patterns, and its potential as a biomarker or therapeutic target. Commercial HSD17B2 antibodies are typically raised in hosts like rabbits or mice, with validation data ensuring specificity for human, mouse, or rat isoforms. Researchers rely on this tool to explore hormonal regulation mechanisms and disease associations, advancing insights into endocrine health and disease.

       
HSD17B2抗体;HSD17B2;HSD17B2 Antibody;

公司简介

湖北瑞和宁生物科技有限公司研究创新能力， 拥有完整、科学、质量管理体系。并不断致力于技术创新，产品创新和管理创新，赢得了国内外广大用户的信任。

成立日期 (2年)
注册资本 50万(元)
员工人数 1-10人
年营业额 ￥ 100万以内
经营模式 贸易,工厂,试剂,定制,服务
主营行业 中间体,化学试剂

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