RBMX抗体

+ +

•  

   

     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Hela cells, K562 cells, Primary antibody: P01441(RBMX Antibody) at dilution 1/800, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 5 seconds    

  
  

•  

   

     The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P01441(RBMX Antibody) at dilution 1/45. (Original magnification: ×200)    

  
  

The RBMX antibody targets the RNA-binding motif protein X-linked (RBMX), a conserved RNA-binding protein encoded by the X chromosome. RBMX, also known as hnRNP G, plays critical roles in RNA metabolism, including splicing, stability, and transport. It contains an N-terminal RNA recognition motif (RRM) and a C-terminal glycine-rich domain, enabling interactions with RNA and other proteins. RBMX is implicated in regulating alternative splicing of genes involved in cell cycle control, DNA repair, and neuronal functions. Dysregulation of RBMX has been linked to cancer progression, neurodevelopmental disorders, and neurodegenerative diseases like ALS.

RBMX antibodies are widely used in research to study its expression, localization, and molecular interactions via techniques like Western blotting, immunohistochemistry, and immunoprecipitation. Studies utilizing these antibodies have revealed RBMX's role in maintaining genomic stability, modulating sex chromosome genes, and influencing gender-biased gene expression due to its X-linked nature. Recent work highlights its involvement in liquid-liquid phase separation and stress granule formation under cellular stress. As RBMX deficiency or mutation impacts multiple pathways, its antibody serves as a crucial tool for investigating RNA-protein networks in disease mechanisms and potential therapeutic targets.