GTPBP10抗体

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     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: A549 cells, Primary antibody: P01430(GTPBP10 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 minutes    

  
  

GTPBP10 (GTP-binding protein 10) is a member of the GTPase family involved in RNA processing and mitochondrial function. It shares structural homology with Obg-like ATPases and is implicated in ribosomal RNA (rRNA) modification, particularly in the methylation of mitochondrial rRNA. Studies suggest GTPBP10 interacts with proteins like MRM2 and methyltransferases, contributing to mitochondrial ribosome assembly and translational fidelity. Dysregulation of GTPBP10 has been linked to mitochondrial disorders and cancer, where altered expression may affect cellular energy metabolism and proliferation pathways.

The GTPBP10 antibody is a critical tool for detecting and quantifying GTPBP10 protein levels in research. It enables the investigation of GTPBP10's subcellular localization (primarily mitochondrial), expression patterns across tissues, and interactions with molecular partners. Commonly used in techniques like Western blotting, immunofluorescence, and immunohistochemistry, this antibody helps validate GTPBP10 knockdown/knockout models and assess its role in disease contexts. Recent studies utilize it to explore GTPBP10's potential as a biomarker in tumors or its involvement in neurodegenerative conditions linked to mitochondrial dysfunction. Validation via siRNA-mediated silencing or CRISPR-Cas9 editing ensures antibody specificity, supporting mechanistic insights into GTPBP10's biological and pathological functions.