GALK1抗体

+ +

•  

   

     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Human fetal liver tissue, Primary antibody: P01395(GALK1 Antibody) at dilution 1/450, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 30 seconds    

  
  

•  

   

     The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P01395(GALK1 Antibody) at dilution 1/40. (Original magnification: ×200)    

  
  

•  

   

     The image is immunohistochemistry of paraffin-embedded Human brain  tissue using P01395(GALK1 Antibody) at dilution 1/40. (Original magnification: ×200)    

  
  

The galactokinase 1 (GALK1) antibody is a tool used to detect and study GALK1. an enzyme encoded by the *GALK1* gene that catalyzes the first step of galactose metabolism by phosphorylating galactose to galactose-1-phosphate. GALK1 is primarily expressed in the liver and plays a critical role in the Leloir pathway, which converts dietary galactose into glucose-1-phosphate for energy production. Dysregulation or mutations in GALK1 are linked to type II galactosemia, a rare autosomal recessive disorder characterized by galactose accumulation, leading to complications such as cataracts and neurological issues.

The GALK1 antibody is widely utilized in research to investigate the enzyme's expression, localization, and function in cellular and tissue contexts. It is employed in techniques like Western blotting, immunohistochemistry, and immunofluorescence to assess protein levels in disease models, genetic studies, or metabolic analyses. Recent studies also explore GALK1's potential role beyond galactosemia, including its involvement in cancer progression, as altered galactose metabolism may influence tumorigenesis. Additionally, the antibody aids in characterizing genetic variants or mutations affecting GALK1 activity, contributing to diagnostic and therapeutic research for metabolic disorders. Its specificity and reliability make it essential for elucidating galactose-related pathways and their broader physiological implications.